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Purpose: Functional TRPV1 and TRPA1 channel subtype expression occurs both on corneal epithelial and stromal fibroblasts as well as on afferent sensory nerves.Blockage of TRPV1 activation in cultured human corneal epithelial cells retards wound healing even though it improves stromal wound healing by suppressing fibrosis and inflammation in vivo.To validate these opposing effects in vivo of these two different TRP channel subtypes, we determined if the epithelial and stromal wound healing responses are differentially affected by loss of TRPV1 and TRPA1 functional expression.