【摘 要】
：
Purpose To investigate the association of PLEKHA7 and COL11A1 with primary angle closure glaucoma, as well as acute and chronic subphenotype, in a Han Chinese population.Methods 984 cases, including 6
【机 构】
：
Department of Ophthalmology and Vision Science,Shanghai Medical College,Eye and Ear Nose Throat Hosp
【出 处】
：
第十七届亚非眼科大会暨中华医学会第十九次全国眼科学术大会
论文部分内容阅读
Purpose To investigate the association of PLEKHA7 and COL11A1 with primary angle closure glaucoma, as well as acute and chronic subphenotype, in a Han Chinese population.Methods 984 cases, including 606 primary angle closure glaucoma (PACG) and 378 primary angle closure (PAC),and 922 normal controls were recruited.12 single nucleotide polymorphisms (SNPs) (rs1676486, rs3753841,rs12138977, rs2126642, rs2622848, rs216489,rs1027617, rs366590, rs11024060, rs6486330,rs11024097, and rs11024102) in the PLEKHA7 gene and COL11A12 gene were genotyped.SNP genotyping was performed using iPLEX Gold chemistry on the MassARRAY system.Distributions of allele frequencies were compared between cases and controls as well as in patient subgrouos with or without acute attacks.
其他文献
Purpose To observe the safety and efficacy of liquid infiltration method to separate lenticule in small incision lenticule extraction (SMILE).Method prospective study.72 patients were included in the
Purpose: To describe a "two-dimensional" method, that analyzes refractive outcome after toric intraocular lens (IOL) implantation, taking axis misalignment of toric IOL into account.Methods: A mathema
Objective To determine longitudinal changes in angle configuration in eyes of primary angle closure suspects (PACS) treated by laser peripheral iridotomy (LPI) and in untreated fellow eyes.Design Long
Purposelnitially asymptomatic diseases such as glaucoma and diabetic retinopathy are becoming rapidly more prevalent in China, and focus group studies suggest that patients may not understand the need
Purpose: Phenotypic correlation between parents and offspring has been commonly used to estimate the heritability assuming the parents and offspring share the same environment.However, it is well know
Purpose To investigate the pharmacogenetic associations between genetic risk variants of age-related macular degeneration (AMD) and long-term outcome after intravitreal anti-vascular endothelial growt
PURPOSE To evaluate the effect of pupil dilation on anterior chamber angle (ACA) measurements obtained by spectral-domain optical coherence tomography (SDOCT).METHODS A total of 40 eyes from 20 health
Purpose To determine corneal viscoelasticity by Ocular Response Analyser (ORA) and investigate the relationship between corneal biomechanical properties and visual field (VF) progression in normal ten
There has emerged a lot of discussion on the link between retinal ganglion cells and emotion.Our previous studies showed that different doses of corticosterone were able to induce different extent of
Purpose To investigate the surgical outcomes of 23-gauge pars plana lensectomy combined with gonioplasty for phacomorphic glaucoma with an extremely shallow anterior chamber.Method Observe and record