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Purpose To investigate the pharmacogenetic associations between genetic risk variants of age-related macular degeneration (AMD) and long-term outcome after intravitreal anti-vascular endothelial growth factor (VEGF) treatment in Korean neovascular AMD patients.Design Prospective cohort study.Participants A cohort of 394 treatment-naive patients (394 eyes) that underwent intravitreal anti-VEGF treatment for neovascular AMD.