【摘 要】
：
The influenza virus is a single-stranded negative-sense RNA virus, and transcription and replication of the virus genome occur in the nucleus.Viral infectio
【机 构】
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DepartmentsofBiologicalInformaticsandExperimentalTherapeutics,AkitaUniversityGraduateSchoolofMedicin
【出 处】
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第四届吴宪吴瑞国际学术研讨会、第九届全国医学生物化学与分子生物学、第六届全国临床应用生物化学与分子生物学联合学术讨论会
论文部分内容阅读
The influenza virus is a single-stranded negative-sense RNA virus, and transcription and replication of the virus genome occur in the nucleus.Viral infection is generally associated with virus-driven hijacking of the host factors.Regarding anti-influenza drug development,currently licensed anti-influenza drugs target viral M2 or NA proteins.Most of the influenza strains exhibit resistance to M2 inhibitors (e.g.amantadine) and the strains have recently emerged that show resistance to NA inhibitors (e.g.oseltamivir).Thus, there is an urgent need to develop more effective antiviral therapeutics against influenza virus infection, which should be less resistant and importantly effective for critically ill patients.The potential anti-influenza viral strategies are classified according to their target: the viral proteins, the host factors involved in virus replication mechanisms,and the host factors regulating host immune responses.
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