【摘 要】
：
Significant progress in dissecting neural connections has been made using optical imaging with fluorescence labels, especially in dissecting local connectio
【机 构】
：
BrittonChanceCenterforBiomedicalPhotonics,WuhanNationalLabforOptoelectronics,HuazhongUniversityofSci
【出 处】
：
第四届吴宪吴瑞国际学术研讨会、第九届全国医学生物化学与分子生物学、第六届全国临床应用生物化学与分子生物学联合学术讨论会
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Significant progress in dissecting neural connections has been made using optical imaging with fluorescence labels, especially in dissecting local connections.However,acquiring and tracing brain-wide, long-distance neural circuits at the neurite level remains a substantial challenge.We obtained a three-dimensional structural data set of a Golgistained whole mouse brain at the neurite level with our developed Micro-Optical Sectioning Tomography (MOST) system, which directly demonstrates the whole-brain structural connectivity at the neurite level in a standard format.I will clarify the unique features of the MOST, which is a novel microscopic optical imaging technique aiming at providing a submicron resolution by sectioning.Combined with a modified Nissl staining method, we first demonstrate the 3D cellular and vascular configurations at the level of individual cells and capillaries in the whole mouse brain.
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