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Cytopenias resulting from the impaired generation of normal blood cells from hematopoietic precursors are important contributors to morbitity and mortality in leukemia.However,the process by which normal hematopoietic cells are overtaken by emerging leukemia cells and how different subsets of hematopoietic stem cells (HSCs) and progenitor cells (HPCs) are distinctly influenced during leukemic cell infiltration is poorly understood.