【摘 要】
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Parkinsons disease(PD) is a common chronic neurodegenerative disorder,which is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra and the dopamine loss in the st
【机 构】
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Department of Neurology, First Hospital Affiliated Hebei Medical University, Shijiazhuang 050031, Ch
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Parkinsons disease(PD) is a common chronic neurodegenerative disorder,which is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra and the dopamine loss in the striatum.There are over 2,000,000 PD sufferer in our country,and the morbidity rate of the aged people over 65 years is up to 2%,which seriously threatens the health and life quality of the aged people,even results in disabled.Levodopa can effectively alleviate the symptoms of PD,but its pharmaceutical effects will gradually lose following long-time treatment and various dyskinesias will appear.Currently,more and more researches were focus on the transplantation therapy for diseases of central nervous system.The study of neural stem cells (NSCs) provides a new way of thinking for the cell transplantation.Since Woodbury et al had found that bone marrow stromal cells (BMSCs) could be induced to differentiate into neurons in vitro at 2000,BMSCs had also been used for the study on therapy for PD,stroke and degenerative diseases of central nervous system and so on.To compare therapeutic effect of the transplantation of NSCs or BMSCs on PD model rats,we investigated behavioral change and the survival and differentiation of the cells transplanted into the brain of PD model rats.
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