Rat cytokine antibody array analysis of effective ingredient that BMSCs-CM induce NSCs into high pro

• 作 者: Ping GU Qin-Ying MA Yan-Yong WANG Ya WEN Ming-Wei WANG Dong-Sheng CUI Li LIU Yuan GENG
• 机 构: Department of Neurology, First Hospital of Hebei Medical University, Shijiazhuang 050031;Key Laborat
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年12期
• 关键词: neural stem cells bone marrow stromal cells neurons conditioned medium protein a

　　Bone Marrow Stromal cells(BMSCs) are mesenchymal elements that normally provide structural and functional support for hematopoiesis.The cytokines and growth factors excreted by BMSCs consist the microenvironment which plays a crucial role in haemopoietic stem cells differentiation and development.Studies show that the cytokines and growth factors that regulate haemopoietic stem cells could also regulate central and peripheral nervous system.Our former research have confirmed that BMSCs can directly regulate the differentiation of Neural stem cells (NSCs) into high proportional neurons,furthermore the dissolvable molecules excreted by BMSCs play a key role during this process,surpported by the study of Bone Marrow Stromal cells conditioned medium(BMSCs-CM).The ingredient of BMSCs-CM plus 2%B27 supplement is too complicated to be analyzed.