A Lysosomal TRP Channel Regulates Large Particle Phagocytosis via Focal Exocytosis

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：matrix521

【摘要】

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【作者】

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Qiong Gao Mohammad Samie Haoxing Xu

【机构】

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University of Michigan, Ann Arbor, USA

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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Phagocytosis lysosomal exocytosis Phagosome Membrane trafficking Ca2+release and

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Phagocytosis of cellular particles such as apoptotic bodies is required for tissue remodeling and cellular clearance.Particle binding triggers a cascade of signaling locally to orchestrate focal cytoskeleton reorganization and delivery of membranes from intracellular pools, resulting in the extension of plasmalemmal pseudopods.Lysosomal membrane is a major source of intracellular membrane required for particle ingestion, and is delivered to phagocytic cups via Ca2+-dependent "focal" exocytosis.

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A Lysosomal TRP Channel Regulates Large Particle Phagocytosis via Focal Exocytosis

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