Tandam KChIP4a/Kv4.3 complexes with different number auxiliary subunits exhibit distinct inactivatio

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：wang1hnsc

【摘要】

：

【作者】

：

Jingheng Zhou Yiquan Tang KeWei Wang

【机构】

：

Department of Neurobiology and Neuroscience Research Institute, Peking University School of Medicine

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

：

2013年2期

【关键词】

：

KChIP Kv4.3

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Cytoplasmic Kv channel-interacting proteins (KChIPs) associate with pore-forming Kv4 a-subunits to form channel complexes that encode the somato-dendritic A-type K+ current (IsA) in neurons and transient outward current (Ito) in cardiac myocytes.All KChIP isoforms contain a highly conserved C-terminal core domain that interacts with two neighboring Kv4 N-terminal domains to function as a molecular clamp to enhance membrane expression, whereas their N-terminus alters the channel gating.

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Tandam KChIP4a/Kv4.3 complexes with different number auxiliary subunits exhibit distinct inactivatio

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