Inhibition of TRPC channels by the cardioprotective drug sodium tanshinone ⅡA sulfonate

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：Truth_Tiger

【摘要】

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【作者】

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Bo Zeng Gui-Lan Chen Yan Yang Xiao-Rong Zeng

【机构】

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Luzhou Medical College, China

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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TRPC channels sodium tanshinone ⅡA sulfonate cardiac hypertrophy

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Sodium tanshinone ⅡA sulfonate (STS) is a water-soluble derivative of tanshinone ⅡA, the major lipophilic component extracted from the root of Danshen (Salvia miltiorrhiza).STS is clinically used in the treatment of myocardial infarction,coronary artery disease and other cardiovascular disorders.It has been found in recent years that STS protected the heart against pathological hypertrophy in laboratory animals.However, the direct molecular targets of STS on cardiomyocytes are still unclear.Here we examined the effect of STS on the activity of TRPC channels, which have been suggested to be important mediators of pathological cardiac hypertrophy.

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Inhibition of TRPC channels by the cardioprotective drug sodium tanshinone ⅡA sulfonate

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