【摘 要】
：
Kvl.3 channel is a delayed rectifier channel abundant in human T lymphocytes.Chronic inflammatory and autoimmune disorders lead to the over-expression of Kvl.3 in T cells;however, the kinetics feature
【机 构】
：
Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Tec
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
论文部分内容阅读
Kvl.3 channel is a delayed rectifier channel abundant in human T lymphocytes.Chronic inflammatory and autoimmune disorders lead to the over-expression of Kvl.3 in T cells;however, the kinetics features, regulatory mechanism and physiological function of Kvl.3 in T cells remain elusive.In this study, we firstly established a kinetic model capable to precisely replicate all the kinetic features for Kvl.3 channels, and then constructed a T-cell model composed of ion channels including Ca2+-release activated calcium (CRAC) channel, intermediate K+ (IK) channel, TASK channel and Kv1.3 channel for simulating the changes in membrane potentials and local Ca2+ signaling messengers during activation of T cells.Based on the experimental data from current-clamp recordings, we successfully demonstrated that Kvl.3 not CRAC dominated the membrane potential of T cells to manipulate the Ca2+ influx via the pore of CRAC channel.
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