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  5. Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism

Divalent cations modulate TMEM16A calcium-activated chloride channels by a common mechanism

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：haojiubujian123
【摘 要】
：
The gating of Ca2+-activated Cl-channels (CaCCs) is controlled by a complex interplay among [Ca2+]I, membrane potential (Vm), and permeant anions.Besides Ca2+, Ba2+ also can activate both TMEM16A and
【作 者】
：
Hongbo Yuan Chongsen Gao Yafei Chen Yong Zhan Hailong An 
【机 构】
：
Hebei University of Technology
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
TMEM16A Divalent cation Regulation Patch clamp 
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The gating of Ca2+-activated Cl-channels (CaCCs) is controlled by a complex interplay among [Ca2+]I, membrane potential (Vm), and permeant anions.Besides Ca2+, Ba2+ also can activate both TMEM16A and TMEM16B as well.This study reports the effects of several divalent cations as regulators of TMEM16A channels stably expressed in HEK293 cells.
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