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Parkinsons disease (PD) is the second most common neurodegenerative disease and afflicts almost 1.8％ of over 65-year-old group in the world.Epidemiological projections showed that the incidence of PD was increasing continuously each year,with a wider age range as well.A large number of studies indicated that voltage-gated potassium channel (Kv) played significant roles in cellular signaling in both excitable and non-excitable cells.