Short-term plasticity encoded within voltage-gated potassium channels of central neurons

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：realg007

【摘要】

：

【作者】

：

Yi-Mei Yang Wei Wang Michael J Fedchyshyn Zhuan Zhou Jiuping Ding Lu-Yang Wang

【机构】

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SickKids & Univ.Toronto, Canada Huazhong Univ.Sci

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

：

potassium channels short-term plasticity

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Central neurons encode information in bursts of action potentials (APs/spikes), but little is known about the gating behavior of voltage-gated ion channels during repetitive spike firing.We discover that when evoked by a pair or short burst of APs,currents mediated by voltage-gated potassium channels (Kvs) in central neurons facilitate in a frequency and voltage-dependent, but surprisingly Ca2+-independent manner.

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Short-term plasticity encoded within voltage-gated potassium channels of central neurons

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