Cardiac pH-sensitive Channels Contribute to Myocardial Ischemic Injury

• 作 者: Jian-Guo Chen Fang Wang Zhuang-Li Hu
• 机 构: Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, C
• 出 处: The 4th International Ion Channel Conference(第四届国际离子通道会议)
• 发表日期: 2013年2期
• 关键词: acid-sensing ion channels (ASICs) transient receptor potential vanilloid 1 (TRPV

Aims: Acid-sensing ion channels (ASICs) and transient receptor potential vanilloid 1 (TRPV1) are pH-sensitive channels.Although they were initially found in the nervous system, more and more attentions have been attracted to other tissues, especially the cardiovascular system.The aims of this study are to identify the existence of ASICs and TRPV1 in the heart of rodents, and to examine the roles of these pH-sensitive channels in pathophysiology of myocardial ischemia.