Tannic acid inhibits the excitability of small DRG neurons and the ionic mechanisms

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：yuzhou519

【摘要】

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Tannic acid is present in relatively high concentrations in red wines and green teas and has been proposed to be involved in multiple beneficial health effects.In this study, we revealed the efficacy

【作者】

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Xuan Zhang Hai-lin Zhang

【机构】

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Department of Pharmacology, Hebei Medical University, Shijiazhuang, China

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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Tannic acid pain DRG M-type K+currents Na+current Ca2+-activated Cl-currents

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Tannic acid is present in relatively high concentrations in red wines and green teas and has been proposed to be involved in multiple beneficial health effects.In this study, we revealed the efficacy of tannic acid for potent suppression of the excitability of rat dorsal root ganglion (DRG) neurons and the underlying mechanisms were further investigated.A perforated whole-cell patch technique was performed on rat small DRG neurons and HEK293 cells.In rat small DRG neurons, tannic acid enhances M-type K+ currents but inhibits.

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Tannic acid inhibits the excitability of small DRG neurons and the ionic mechanisms

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