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Adverse drug side effect, such as cardiotoxicity, is a major concern in drug development and a major cause of drug withdrawal from the market.Most of these drugs appear to interfere with the well-choreographed and elaborate movement of ions across cardiomyocytes membrane disrupting the electrical activity and beating of the heart.It is imperative to emphasize that while studying the effect of drug candidates on individual ion channels and cellular events may provide useful information, what is really needed is a functional assay system that can assess the integrated cardiac response to drug candidates.