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  5. 50-state kinetic model provides insight into mechanism of vasoregulation by β1 subunits of calcium-a

50-state kinetic model provides insight into mechanism of vasoregulation by β1 subunits of calcium-a

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：flexrhythm
【摘 要】
：
Large-conductance voltage-and Ca2+-activated potassium (BK) channels exhibit substantial kinetic and functional differences, mainly arising from tissue-specific expression of auxiliary β subunits.The
【作 者】
：
Feng Xiao Zheng Zhang Wei Wang Ming Yuchi Jiuping Ding 
【机 构】
：
Key laboratory of Molecular Biophysics of the Ministry of Education College of Life Science and Tech
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
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Large-conductance voltage-and Ca2+-activated potassium (BK) channels exhibit substantial kinetic and functional differences, mainly arising from tissue-specific expression of auxiliary β subunits.The β1-subunit, associated with the BK pore-forming mSlolα subunit, is enriched in smooth muscle (SM) and plays an important role in regulating relaxation of arterial smooth muscle based on the experimental data of β1-knockout (KO) mice.
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