A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：sgzhou22

【摘要】

：

Biological membranes, including both plasma membrane and those compartmenting subcellular organelle, have provided the basis of bioelectrical gradients.Hence, almost all membrane proteins function at

【作者】

：

Huaiyu Yang Zhaobing Gao Ping Li Kunqian Yu Ye Yu Tian-Le Xu Min Li Hualiang Jiang

【机构】

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Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

【出处】

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The 4th International Ion Channel Conference(第四届国际离子通道会议)

【发表日期】

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2013年2期

【关键词】

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Voltage sensitivity Kv1.2 Molecular dynamics simulation

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Biological membranes, including both plasma membrane and those compartmenting subcellular organelle, have provided the basis of bioelectrical gradients.Hence, almost all membrane proteins function at certain biological membrane potential which often changes during biological processes.This electrical potential change regulates membrane protein function.Therefore, voltage sensing of a given protein is critical to confer conversion of a change in membrane potential to signaling activities underlying a variety of physiological processes.

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A Theoretical Model for Calculating Voltage Sensitivity of Ion Channels and the Application on Kv1.2

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