G-quadruplex structure stabilizers inhibit tumorigenic properties of cancer cells through multiple c

来源 :第十五届亚太分子生物学网络组织年会 | 被引量 : 0次 | 上传用户：cjjelly

【摘要】

：

Carbazole derivatives that stabilized G-quadruplex DNA structure formed by human telomeric sequence have been designed and synthesized. Among them,3,6-bis(1-met

【作者】

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Jing-Jer Lin

【机构】

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InstituteofBiochemistryandMolecularBiologyNationalTaiwanUniversityCollegeofMedicine

【出处】

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第十五届亚太分子生物学网络组织年会

【发表日期】

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2012年10期

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Carbazole derivatives that stabilized G-quadruplex DNA structure formed by human telomeric sequence have been designed and synthesized. Among them,3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide ( BMVC) and 3,6-bis(4-methyl-2-vinylpyrazinium) carbazole diiodine (BMVC4) bound and stabilized G-quadruplex structure and had potent inhibitory effects against telomerase activity.The cellular effects of both BMVC and BMVC4 were characterized in cancer cells.These two compounds repressed tumor progression through both telomeredependent and telomere-independent pathways.

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