【摘 要】
：
Diabetes mellitus is one of the most common metabolic diseases characterized by elevated levels of serum glucose.Though insulin resistance and insulin secretion
【机 构】
：
ShanghaiInstituteofBiochemistryandCellBiology,CAS
【出 处】
：
第十五届亚太分子生物学网络组织年会
论文部分内容阅读
Diabetes mellitus is one of the most common metabolic diseases characterized by elevated levels of serum glucose.Though insulin resistance and insulin secretion are known to play critical roles in the development of diabetes,its underlying molecular events remain unclear and controversial.In our previous study,calcium/calmodulindependent protein serine kinase (CASK),a key protein in protein-targeting and vesicle transport in neurons,was found to be involved in insulin signaling pathway.
其他文献
Iron is an essential element but possesses potential toxicity for aerobic lives.Ferritin,a large protein complex with high capacity of iron incorporation,can se
目的:(1) 发现并证实睾酮合成相关新的锌转运体——ZnT8.(2) 阐明ZnT8 参与睾酮合成的机制.方法:应用免疫荧光双标和激光共聚焦扫描显微镜及Western Blot 技术获取ZnT8 在小
Lycopene is generally consumed and known for its antioxidant activities.In this study,we hypothesized that lycopene can prevent iron-mediated oxidative stress,p
This study investigated the association of 6 sortilin-related receptor l ( SORLI ) variants with cognitive impairment.SORLI SNPs 8.9.10,13.19 and 23
金属离子在生命体系的各项生理活动中扮演着不可缺少的角色,例如Cu,Zn,Mo 等微量元素.然而当环境中某些重金属离子浓度过高时,它们所引起的生理毒性又威胁着生命体的生存.因
Aminoacyl-tRNA synthetases (ARSs) ligate specific amino acids to their cognate tRNAs in protein synthesis process.In higher eukaryote,nine ARSs form multi-synth
目的:通过观察锌预处理对神经病理性疼痛(NPP)模型小鼠的影响,探讨锌离子参与NPP 的可能途径.方法:选用NPP 小鼠模型作为研究对象,采用动物行为学观察、金属自显影、TSQ 荧光
Muscle atrophy occurs in many diseases such as diabetes.obesity,cancer.cardiovascular disease.and aging.Starvation is the major known reason for muscle atrophy.
The fidelity of protein biosynthesis requires the aminoacylation of tRNA with its cognate amino acid catalyzed by aminoacyl-tRNA synthetase with high levels of
Although human lysyl-tRNA synthetase (KRS),an enzyme for protein synthesis,is often highly expressed in various cancer cells,its pathophysiological implications