AIMP3p18, a cofactor of multisynthetase complex regulates translational initiation via the formation

来源 :第十五届亚太分子生物学网络组织年会 | 被引量 : 0次 | 上传用户：long5139

【摘要】

：

Aminoacyl-tRNA synthetases (ARSs) ligate specific amino acids to their cognate tRNAs in protein synthesis process.In higher eukaryote,nine ARSs form multi-synth

【作者】

：

Taehee Kang

【机构】

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MedicinalBioconvergenceResearchCenterSeoulNationalUniversity

【出处】

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第十五届亚太分子生物学网络组织年会

【发表日期】

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2012年10期

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Aminoacyl-tRNA synthetases (ARSs) ligate specific amino acids to their cognate tRNAs in protein synthesis process.In higher eukaryote,nine ARSs form multi-synthetase complex (MSC) with three cofactors designated ARS-interacting multifunctional proteins (AIMPs).Among them,AIMP3 is translocated to the nucleus to activate p53 through the interaction with ATM and ATR in response to DNA damage.MRS,which is related with translation initiation through the initiator tRNA,strongly binds with AIMP3 in the MSC.

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AIMP3p18, a cofactor of multisynthetase complex regulates translational initiation via the formation

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