Iron accumulation is considered to be involved in the pathogenesis of Parkinson’s disease (PD).The aim of present study is to investigate the mechanism involve
Dysregulation of iron homeostasis is involved in the pathological process of Alzheimer’s disease (AD).We have recently reported that divalent metal transporter
Objective: To study the mechanism of overexpression of mitochondrial ferritin(MtFt) for inhibiting euroblastoma cells proliferation.Method: electedtFt-SY5Y cell
Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression levels of the frataxin gene (FXN) due to expansion of
Graphene oxide (GO) displays promising properties for biomedical applications including drug delivery and cancer therapeutics.However,GO exposure also raises sa
Cellular zinc influx and efflux are maintained by two major transporter families,ZIP (SLC39A) and ZnT (SLC30A or CDF).The functions for ZIP11/SLC39A11 remain un
Iron is an essential element but possesses potential toxicity for aerobic lives.Ferritin,a large protein complex with high capacity of iron incorporation,can se
Lycopene is generally consumed and known for its antioxidant activities.In this study,we hypothesized that lycopene can prevent iron-mediated oxidative stress,p