The Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiatio

来源 :第十五届亚太分子生物学网络组织年会 | 被引量 : 0次 | 上传用户：xinglink

【摘要】

：

The Mediator complex functions as a control center orchestrating diverse signalings,gene activities.and biological processes.However,how Mediator subunits deter

【作者】

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Gang Wang

【机构】

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ShanghaiInstituteofBiochemistryandCellBiology,CAS

【出处】

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第十五届亚太分子生物学网络组织年会

【发表日期】

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2012年10期

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The Mediator complex functions as a control center orchestrating diverse signalings,gene activities.and biological processes.However,how Mediator subunits determines distinct cell fates remains to be fully elucidated.Here,we show that Mediator MED23 controls the cell fate preference that directs differentiation into smooth muscle cells (SMCs) or adipocytes.Med23 deficiency facilitates SMC differentiation but represses adipocyte differentiation from the multipotent mesenchymal stem cells.

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