【摘 要】
：
Hereditary colorectal cancer syndromes are classified according to the presence of unusually large number of adenomatous or hamartomatous polyps, or their absence.The latter category includes.Lynch sy
【机 构】
：
Department of Medical Laboratory Technology College of Health Sciences University of Sharjah United
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Hereditary colorectal cancer syndromes are classified according to the presence of unusually large number of adenomatous or hamartomatous polyps, or their absence.The latter category includes.Lynch syndrome (hereditary non-polyposis colorectal cancer, HNPCC), which refers to autosomal dominant predisposition to colorectal, endometrial, and a spectrum of other cancers.The syndrome is due to heterozygous germ line mutations in one of the mismatch repair genes MLH1, MSH2, MSH6, and PMS2.Amsterdam Ⅰ and Ⅱ criteria for clinical diagnosis and Bethesda guidelines for molecular testing of suspected patients usually point out additional families in which there is no evidence of mismatch repair deficiency.Hence, the term "Lynch syndrome" should be restricted to those families with germ line mutations in one of the mismatch repair genes.
其他文献
Several studies with Gas-Chromatography/Mass-Spectrometry (GC-MS) have shown that micro-organisms produce patterns of volatile organic compounds (VOCs) that are affected from the type and age of cultu
Chronic infection with Helicobacter pylori, a Gram-negative gastric pathogen designated as a Class Ⅰ carcinogen, is a major risk for stomach cancer in humans.Gastric cancers, and in particular gastric
The incidence of adenocarcinoma of the esophagus is dramatically increasing in Western world.It has become the 7th leading cause of cancer death.Survival of esophageal cancer is stage-dependent.Pre-op
Novel chemotherapeutic agents derived from bioactive phytochemicals could be used as adjuvants and improve the anticarcinogenicity of standard drug treatments.Our recent studies have shown that herbal
The mechanism accounting for metastasis in prostate cancer is not well understood.Transition of cancer cells to a metastatic phenotype within the primary tumor site may involve the loss of the epithel
Gastric cancer remains one of the most frequent killers worldwide.The endogastric capsule (EC) can represent an easy, discomfort free and non-invasive tool on screening programs for early diagnosis of
During the past number of years, the effort of my team has been focused on the identification of genes involved in the malignant progression of prostate cancer.We have used the differential display me
Colorectal cancer (CRC) is one of the commonest cancers wordwide.The risk factors for CRC are both environmental and genetic.Approximately 75% of CRCs are sporadic; the rest are hereditary or belong t
Current immunomagnetic enrichment (IE) method can only detect general epithelial antigens of circulating tumor cells (CTCs).Further characterization of the CTCs to provide specific information on the
Neoadjuvant chemoradiation followed by surgery is standard of care for locally advanced rectal cancer.The impact of pathologic response remains unclear.We reviewed the impact of pathologic response on