DOWNREGULATION OF PARP-1 BY A VIRAL PROCESSIVITY FACTOR TO FACILITATE KSHV LYTIC REPLICATION

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户：kaizhan

【摘要】

：

Poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear protein that catalyzes the serial transfer of the ADP-ribose moiety of NAD+ to various target pro

【作者】

：

Woo-Chang Cheong Joo-Hee Park Hye-Ri Kang Seungbo Ryu Moon Jung Song

【机构】

：

DepartmentofBiosystemsandBiotechnology,DivisionofBiotechnology,CollegeofLifeSciencesandBiotechnology

【出处】

：

17th International Workshop on Kaposi’s Sarcoma Associated H

【发表日期】

：

2014年7期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Poly (ADP-ribose) polymerase-1 (PARP-1) is an abundant nuclear protein that catalyzes the serial transfer of the ADP-ribose moiety of NAD+ to various target proteins.PARP-1 as a multifunctional protein is known to participate in regulation of both DNA repair and transcription.In Kaposis sarcoma-associated herpesvirus (KSHV) infection, PARP-1 acts as a negative regulator of lytic replication via poly ADP-ribosylating RTA, leading to the repression of RTA.

其他文献

VIRION-LIKE VESICLES ARE INDUCED FROM THE NUCLEAR MEMBRANE BY MHV-68 NUCLEAR EGRESS COMPLEX IN MAMMA

Herpesvirus nascent capsids, after assembly in the nucleus, undergo a process of primary envelopment at the inner nuclear membrane, resulting in escape of capsi

会议

ONCOGENIC HERPESVIRUS KSHV HIJACKS BMP-SMAD1-ID SIGNALING TO PROMOTE TUMORIGENESIS

Kaposis sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposis sarcoma (KS), a malignancy commonly found in AIDS patients.Whether KS is a tru

会议

A RHESUS RHADINOVIRUS VIRAL INTERFERON REGULATORY FACTOR IS VIRIONASSOCIATED AND INHIBITS THE EARLY

The interferon (IFN) response is the earliest host immune response dedicated to combating viral infection.Because of this, many viruses have evolved strategies

会议

MOUSE KAPOSI SARCOMA IS A KSHV-INDUCED MURINE NEOPLASM DRIVEN BY PDGFRA AND A VALID EXPERIMENTAL SUR

One of the major impediments in studying Kaposis sarcoma viral oncogenesis are the lack of a cogent unifying pathogenesis hypothesis and the disconnections betw

会议

THE URACIL DNA GLYCOSYLASE OF MURINE GAMMAHERPESVIRUS 68 PROMOTES VIRAL REPLICATION IN FIBROBLASTS A

Uracil DNA glycosylases preserve the fidelity of DNA by catalyzing the removal of uracils.Moreover, B-lymphocytes utilize UNG activity in the development of the

会议

KSHV INDUCTION OF HO-1 IN ENDOTHELIAL CELLS PROMOTES VIRUS INFECTION AND TUMORIGENESIS, AND OCCURS V

KSHV infection of endothelial cells (EC) in vitro is associated with robust induction of the host gene heme oxygenase-1 (HO-1), a stress-inducible cellular enzy

会议

MONO-UBIQUITINATION OF TEGUMENT PROTEIN ORF45 MEDIATES ITS ASSOCIATION WITH LIPID RAFTS AND REGULATE

A herpesvirus is composed of a viral genomic DNA-containing capsid surrounded by an amorphous protein layer referred to as tegument, and enclosed in a lipid env

会议

SUBVERSION OF THE INFLAMMASOME RESPONSE DURING MURINE GAMMAHERPESVIRUS 68 INFECTION OF PRIMARY MACRO

Kaposis sarcoma associated herpesvirus (KSHV) and other herpesviruses trigger and then subvert inflammasome activation of host cells, but the role of the inflam

会议

P53MDM2 AXIS REGULATES KAPOSI SARCOMA HERPESVIRUS REPLICATION

The switch between latency and virus reactivation (lytic replication) is a critical step in KSHV pathogenesis and transmission.The molecular events that regulat

会议

KSHV ENCODED ORF59 PROTEIN RECRUITS PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5) TO MODULATE CHROMA

Kaposis sarcoma associated herpesvirus (KSHV) persists in a highly ordered chromatin structure during latent infection with majority of the genome having repres

会议

DOWNREGULATION OF PARP-1 BY A VIRAL PROCESSIVITY FACTOR TO FACILITATE KSHV LYTIC REPLICATION

其他学术论文