SUBVERSION OF THE INFLAMMASOME RESPONSE DURING MURINE GAMMAHERPESVIRUS 68 INFECTION OF PRIMARY MACRO

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户：teddycici

【摘要】

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Kaposis sarcoma associated herpesvirus (KSHV) and other herpesviruses trigger and then subvert inflammasome activation of host cells, but the role of the inflam

【作者】

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Brandon Cieniewicz Qiwen Dong Bryan Mounce Vera Tarakanova Adrianus van der Velden Laurie T Krug

【机构】

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DepartmentofMolecularGeneticsandMicrobiology,StonyBrookUniversity,StonyBrook,NY,USA;MolecularandCell

【出处】

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17th International Workshop on Kaposi’s Sarcoma Associated H

【发表日期】

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2014年7期

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Kaposis sarcoma associated herpesvirus (KSHV) and other herpesviruses trigger and then subvert inflammasome activation of host cells, but the role of the inflammasome in gammaherpesvirus pathogenesis is not known.Here we report that virus replication was not impacted by the loss of Caspase 1/11 in bone marrow-derived macrophage cells (BMDMs) or primary fibroblasts.Interestingly, in BMDMs infected with infectious or UV-inactivated murine gammaherpesvirus 68, we found no evidence for the activation of the inflammasome over a 24 hr timecourse.

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SUBVERSION OF THE INFLAMMASOME RESPONSE DURING MURINE GAMMAHERPESVIRUS 68 INFECTION OF PRIMARY MACRO

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