KSHV ENCODED ORF59 PROTEIN RECRUITS PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5) TO MODULATE CHROMA

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户：storm369

【摘要】

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Kaposis sarcoma associated herpesvirus (KSHV) persists in a highly ordered chromatin structure during latent infection with majority of the genome having repres

【作者】

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Roxanne Strahan Maria McDowell Pravinkumar Purushothaman Subhash Verma

【机构】

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DepartmentofMicrobiologyandImmunology/MS320,1664NVirginiaStreet,UniversityofNevada,Reno,SchoolofMedi

【出处】

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17th International Workshop on Kaposi’s Sarcoma Associated H

【发表日期】

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2014年7期

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Kaposis sarcoma associated herpesvirus (KSHV) persists in a highly ordered chromatin structure during latent infection with majority of the genome having repressive marks.However, upon reactivation the landscape of viral chromatin changes into an open chromatin through the involvement of lysine demethylases and methyltransferases.Beside methylation on lysine residues, arginine methylation of histone H4 and H3 has been shown to play an important role in controlling the compactness of the chromatin.

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KSHV ENCODED ORF59 PROTEIN RECRUITS PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5) TO MODULATE CHROMA

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