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目的探讨乳腺癌患者外周血中小黏蛋白(SBEM-mRNA)的表达与乳腺癌微转移的关系。方法利用Nested-RT-PCR技术检测92例乳腺癌术后患者,20例乳腺良性肿瘤患者,10例其他系统恶性肿瘤患者,10例健康人群外周血SBEM-mRNA的表达。结果乳腺癌组外周血SBEM-mRNA表达率为46.7%(43/92),其他各组均为阴性。SBEM表达与ER和PR状态、患者月经状况和肿瘤大小无关;与CEA,CA15-3和Her-2在外周血中的表达状况、患者年龄、腋窝淋巴结转移状况有关,上述5因素分组间差异有统计学意义(P<0.05和0.01)。结论外周血中SBEM-mRNA的表达可作为乳腺癌微转移的一个辅助检测指标。
Objective To investigate the relationship between the expression of SBEM-mRNA and the micrometastasis of breast cancer in patients with breast cancer. Methods Nested-RT-PCR was used to detect the expression of SBEM-mRNA in peripheral blood of 92 patients with breast cancer, 20 patients with benign breast tumors, 10 patients with other malignant tumors and 10 healthy controls. Results The expression rate of SBEM-mRNA in peripheral blood of breast cancer patients was 46.7% (43/92), while the other groups were negative. The expression of SBEM was not associated with ER and PR status, patient’s menstrual status and tumor size. The expression of SBEM was related to the expression of CEA, CA15-3 and Her-2 in peripheral blood, patient’s age and axillary lymph node metastasis. Statistical significance (P <0.05 and 0.01). Conclusion The expression of SBEM-mRNA in peripheral blood can be used as an auxiliary detection index for breast cancer micrometastasis.