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洁霉素(Lincomycin)是由林可链丝菌(Strept-omyces Linconensis 的培养液中提取的抗生素。它的7(R)—脱氧—7(S)—氯衍生物抗菌活性增加4～16倍,称氯洁霉素(Clindamycin)。两药国内均已生产,为了便于临床用药特介绍如下。一、抗菌作用洁霉素和氯洁霉素对革兰氏阳性球菌和多数厌氧菌均有较强的抗菌作用。(一)革兰氏阳性球菌:最低抑菌浓度(Mic)测定表明,洁霉素对绝大多数金黄色葡萄球菌(下称金葡菌)的 Mic 为0.2～0.8μg/ml,个别菌株为16～32μg/ml;肺炎球菌为0.2～1.0μg/ml;链球菌为0.2～0.8μg/ml。氯洁霉素对金葡菌的 Mic 为0.19
Lincomycin is an antibiotic extracted from Streptomyces Linconensis and its antibacterial activity increases 4 to 16 times with 7 (R) -deoxy-7 (S) -chloro derivatives Clindamycin (Clindamycin) .Two drugs have been produced in the country, in order to facilitate the clinical use of special introduced as follows.An antibacterial effect of lincomycin and clindamycin on gram-positive cocci and most anaerobic bacteria are strong (1) Gram-positive cocci: The MIC was determined to be 0.2 ~ 0.8 μg / ml for most Staphylococcus aureus (Staphylococcus aureus) , 16 ~ 32μg / ml for individual strains, 0.2 ~ 1.0μg / ml for pneumococci, and 0.2 ~ 0.8μg / ml for streptococci.Micline of Clindamycin against Staphylococcus aureus was 0.19