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肝性脑病以深度的神经抑制为特征。理论上其神经抑制可为抑制性神经传递增强和/或兴奋性神经传递降低的结果。随着神经生物学和神经药理学的进展,1982年以来Schafer等在动物实验和临床研究的基础上,提出γ-氨基丁酸(GABA)神经递质系统与肝性脑病发病机理有关的假说。
Hepatic encephalopathy is characterized by deep neurological suppression. Its neuro-inhibition in theory may be the result of an increase in inhibitory neurotransmission and / or a decrease in excitatory neurotransmission. With the progress of neurobiology and neuropharmacology, Schafer et al. Proposed the hypothesis about the pathogenesis of hepatic encephalopathy induced by γ-aminobutyric acid (GABA) neurotransmitter system on the basis of animal experiments and clinical studies since 1982.