A strategy for the targeted metabolomics analysis of 11 gut microbiota-host co-metabolites in rat se

来源 :2015年第一届药代动力学朝阳论坛 | 被引量 : 0次 | 上传用户：wudouyuan

【摘要】

：

　　The microbiota-host co-metabolites have proven to be of great importance in physiological studies and their dysregulation has been found to be closely relat

【作者】

：

ZHONGDan-min;ZHANGPei-ting;XIEZhi-yong;

【机构】

：

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 440100, China

【出处】

：

2015年第一届药代动力学朝阳论坛

【发表日期】

：

2015年期

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　　The microbiota-host co-metabolites have proven to be of great importance in physiological studies and their dysregulation has been found to be closely related to various inflammation disorders and beyond.However, simultaneous determination of these endogenous metabolites represents a great challenge.We thus developed an original and feasible method using ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) which made it possible to rapidly quantify 11 metabolites spanning succinate, phenylacetylglutamine, hippurate and trimethylamine metabolic pathways within 10 min.

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A strategy for the targeted metabolomics analysis of 11 gut microbiota-host co-metabolites in rat se

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