Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ische

• 作 者: HUBing-fang[1]GUOYan[2]GarbaczWojciechG.[3]XUMei-shu[3]HUANGHai[4]TsungAllan[4]ShahYatrik[5]LamKarenS.L.[6]HUANGMin[7]XIEWen[3]
• 机 构: Institute of Clinical Pharmacology, Sun Yat-Sen University, Guangzhou 510275, China
• 出 处: 2015年第一届药代动力学朝阳论坛
• 发表日期: 2015年期

　　Fatty acid binding protein 4 (FABP4) has been known as a mediator of infammatory response in the macrophages and adipose tissue, but its hepatic function is poorly understood.The goal of this study is to investigate the role of FABP4 in liver ischemia/reperfusion (I/R), a clinical condition involves both hypoxia and inflammation.To examine the I/R regulation of FABP4, mice were subjected to I/R surgery before being measured for FABP4 gene expression.Both loss-of-function (by using a pharmacological FABP4 inhibitor) and gain-of-function (by adenoviral overexpression of FABP4) were used to determine the functional relevance of FABP4 expression and its regulation during I/R.