Synthesis and characterization of glycosyl 1,2,3-triazole anticancer compounds with hepatic targetin

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：racheal2009

【摘要】

：

　　Since the galactose residues can be recognized by asialoglycoprotein recepter(ASGPR)located in the mammal liver cell surface,and 1,2,3-triazole derivatives

【作者】

：

王坚毅;陈政君;徐姣;杨晓骏;

【机构】

：

广西大学化学化工学院,南宁,530004

【出处】

：

中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

：

2015年期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Since the galactose residues can be recognized by asialoglycoprotein recepter(ASGPR)located in the mammal liver cell surface,and 1,2,3-triazole derivatives possess broad anti-cancer,antibacterial activities,meanwhile,β-elemene can directly act on DNA in the cancer cell nucleus to inhibit or kill tumor cells and improve the immunogenicity of tumor cells.

其他文献

Total Synthesis of Pelorol and Analogues

　　The tetracyclic meroterpenoid natural product pelorol was isolated from sponge D.elegans,and has been identified as an activator of the inositol-5-phosphata

会议

Design,Synthesis and Antitumor Activity of Novel link-bridge and B-Ring Modified CA-4Analogues as Po

　　Tubulin,the major structural component of microtubules,has become a target for the development of anticancer agents.A series of 12 novel acylhydrazone,chalc

会议

Enantioselective Dinuclear Zinc-Catalyzed Michael Addition Reaction of Pyrazolin-5-ones to Nitroalke

　　Pyrazolones and Pyrazolone derivatives have been widely applied to the synthesis of many drugs.[1] For example,edaravone(3-methyl-1-phenyl-2-pyrazolin-5-one

会议

Complex Model Selectivity of Copillar[5]arenes with Haloalkane

　　Pillar[5]arenes are a new class of macrocyclic hosts that have shown excellent host-guest binding properties to the symmetrical guests by the two interactio

会议

Synthesis and Antifungal Activity of Dehydroabietic Acid-Based Thiadiazole-Thiazolidinones

　　Dehydroabietic acid is a constituent of pine oleoresin and can be readily obtained from disproportionated rosin.It has been reported to possess antimicrobia

会议

取代茚衍生物与羰基铼化合物的反应研究

　　与环戊二烯相比，茚的配位形式更具多样性。目前已经发现的茚配体的配位形式超过了十种[1]，且含有茚基的过渡金属配合物比含有环戊二烯基的过渡金属配合物具有更高的反应活

会议

取代茚基配体衍生物羰基铼化合物过渡金属配合物配位形式环戊二烯基反应活性

Rapid microwave assisted synthesis and antiproliferative evaluation of novel steriadal thiazole deri

　　Heterocycles can enhance binding affinity and improve in vitro potency via hydrogen bond interactions.The compounds containing heterocycles had been widely

会议

餐厨废油脂合成钙皂的研究

餐厨废油脂来源于餐饮业、单位食堂及家庭烹炸食物变质后的废弃物,经过化工厂简单的加热去渣、脱水、酸碱中和、过滤沉淀等工艺提取加工得到的。所得产品组成成分的数值发生

会议

废油脂氧化钙皂化钙皂

1-羟基-3-芳胺烷氧基呫吨酮衍生物的合成及其对酪氨酸酶的抑制作用

　　呫吨酮是远志科,藤黄科,龙胆科,桑科等多种药用植物主要活性成分的结构骨架,其衍生物具有抗肿瘤,抗炎,抗疟,PKC 调节,α-葡萄糖苷酶抑制等多种药理活性[1-3]。本论文以水

会议

羟基芳胺化烷氧基酮衍生物合成酪氨酸酶葡萄糖苷酶抑制呫吨酮

(-)-mesembrane和(-)-mesembrine的不对称合成研究

　　Sceletium 生物碱是Sceletium 属植物的代表性化学成分[1]，(-)-mesembrane(1)和(-)-mesembrine(2)属于Sceletium 生物碱，具有抗焦虑、抗成瘾性等多种药理活性[2]。(-)-mese

会议

Sceletium生物碱(-)-mesembrane(-)-mesembrine不对称全合成

Synthesis and characterization of glycosyl 1,2,3-triazole anticancer compounds with hepatic targetin

其他学术论文