【摘 要】
：
呫吨酮是远志科,藤黄科,龙胆科,桑科等多种药用植物主要活性成分的结构骨架,其衍生物具有抗肿瘤,抗炎,抗疟,PKC 调节,α-葡萄糖苷酶抑制等多种药理活性[1-3]。本论文以水
【机 构】
：
广西师范大学化学与药学学院/药用资源化学与药物分子工程教育部重点实验室,桂林541004
【出 处】
：
中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
呫吨酮是远志科,藤黄科,龙胆科,桑科等多种药用植物主要活性成分的结构骨架,其衍生物具有抗肿瘤,抗炎,抗疟,PKC 调节,α-葡萄糖苷酶抑制等多种药理活性[1-3]。本论文以水杨酸、间苯三酚为基本原料,经过缩合、与不同长度的1,ω-二溴代烷反应、芳胺化等步骤,合成了具有不同侧链长度的1-羟基-3-芳胺烷氧基呫吨酮衍生物,获得了30 个新化合物,如下图所示。
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