Total Synthesis of Pelorol and Analogues

来源 :中国化学会全国第十二届有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：benq702

【摘要】

：

　　The tetracyclic meroterpenoid natural product pelorol was isolated from sponge D.elegans,and has been identified as an activator of the inositol-5-phosphata

【作者】

：

LuoYong-jie;ChenHui-xuan;LuGui;

【机构】

：

School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006

【出处】

：

中国化学会全国第十二届有机合成化学学术研讨会

【发表日期】

：

2015年期

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　　The tetracyclic meroterpenoid natural product pelorol was isolated from sponge D.elegans,and has been identified as an activator of the inositol-5-phosphatase SHIP.However,the inadequate quantity of pelorol severely limited its further applications in life science field.Herein,starting from commercially available terpenoid(+)-sclareolide,we have realized the total synthesis of pelorol.Several key steps have been optimized to facilitate the large-scale preparation.

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Total Synthesis of Pelorol and Analogues

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