【摘 要】
：
Indole is a privileged compound in pharmaceutical fragrance,agrochemicals,pigment and material scienceand over the past few years,[1] indole-based derivativ
【机 构】
：
College of Chemistry and Molecular Engineering,Zhengzhou University,Zhengzhou,Henan 450052,China
【出 处】
：
中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
Indole is a privileged compound in pharmaceutical fragrance,agrochemicals,pigment and material scienceand over the past few years,[1] indole-based derivatives have been reported as highly potent agents,for example as neuropathic pain agent,anticancer agent,anti-allergic inflammatory agent,anti-HIV-1 agent,[2] and so on.There has been reported that 5-NO2 trifluoromethylated indole has excellent anti-HIV-1 activity on HIV-1 strains,[3] and many efforts have been devoted to developing efficient and selective synthetic methods to access trifluoromethylated indoles.[4] Herein we developed an efficient methodology for the synthesis of trifluoromethylated indoles using an asymmetric Friedel-Crafts alkylation of indoles with alkyl trifluoropyruvates catalyzed by our dinuclear Zinc-Catalyst and good enantioselectivities and yields were obtained.
其他文献
Fluconazole with two triazole rings has established an exceptional therapeutic record for Candida infections with low toxicity,excellent safety profile and
Carbasalate calcium equimolecular compound of calcium di[2-(acetyloxy)benzoate]and urea[1],it is an analgesic,antipyretic,and anti-inflammatory drug that ca
DNA 在抗肿瘤药物的开发过程中是一种较为理想的生物靶标，而DNA 嵌入剂能够较好的嵌入双螺旋的DNA 碱基对中间，这就为设计DNA 靶向抗肿瘤药物提供了基础。具有平面刚性结构
Pyrazoloquinazolinone is a privileged scaffold frequently found in compounds possessing remarkable pharmacological activities including anti-allergic,anti-p
喹啉类衍生物在药物、农药、染料和化学助剂方面一直占有十分重要的地位，因此，许多有机化学工作者也一直热衷于研究喹啉衍生物的合成方法。但是，传统的化学合成法大多需要使
冠醚与碱金属、碱土金属有良好的配位作用，在过去的数十年中基于大环冠醚络合分离碱金属、碱土金属离子(特别是锂离子)的技术被广泛研究。如冠醚液液萃取法、基于冠醚主体
Naphthalene derivatives are an important class of compounds that can be found in numerous natural products and broadly used in medicinal chemistry,particula
Cis-tetrahydro tarboline ester,i.e(1R,3R)-methyl-1,2,3,4-tetrahydro-1-(3,4-methyl ene-dioxyphenyl)-9H-pyrido [3,4-b]indole-3-carboxylate hydro-chloride is a
The indole and thiophene structure is probably the heterocyclic nucleus that concentrates the most interest because of its presence in a plethora of natural
A short and efficient total synthesis of(+)-Chinensiolide B is reported,starting from commercial available α-santonin in 10 steps with overall yield 18.7%.