【摘 要】
：
Heterocycles can enhance binding affinity and improve in vitro potency via hydrogen bond interactions.The compounds containing heterocycles had been widely
【机 构】
：
College of Chemistry and Material Science,Guangxi Teachers Education University,Nanning 530001,China
【出 处】
：
中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
Heterocycles can enhance binding affinity and improve in vitro potency via hydrogen bond interactions.The compounds containing heterocycles had been widely applied to the field of medicine or pesticide because of its good biological activity [1].Thiazole is an important five-membered aromatic heterocycle possessing N and S atom.Compounds containing thiazole cycle display various biological functions due to its special chemical structure,such as antimicrobial,antiinflammatory,anticancer,anti-HIV-1 etc,and have obtained an extensive application in drugs,pesticides,and materials science etc[2].Recently,some steroidal thiazole derivatives possessing a D-ring fused a thiazole were reported as anti-inflammatory and anti-tumor agents [3].
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