【摘 要】
：
More than 1 million people each year suffer cardiac arrest (CA) and require Cardiopulmonary Resuscitation (CPR).One half of these arrests result in immediate death and of the remaining only about 5% a
【机 构】
：
University of Colorado Denver | Anschutz Medical Campus USA
【出 处】
：
BIT`s 3rd Annual World Congress of NeuroTalk-2012(2012第三届国际神
论文部分内容阅读
More than 1 million people each year suffer cardiac arrest (CA) and require Cardiopulmonary Resuscitation (CPR).One half of these arrests result in immediate death and of the remaining only about 5% are resuscitated to the extent that they are returned to productive lives.Neurological and neuropsychological deficiencies are prevalent in the remaining 95% of patients and up to 60% of survivors have moderate to severe cognitive deficits 3 months after resuscitation.These dismal results persist despite 50 years of work attempting to improve outcome from CA/CPR.Most CA/CPR research has focused on methodological issues (chest compression, electrical therapy, defibrillators, ventilation modes, artificial perfusion) and pharmacological approaches.It is known that sex difference is a risk factor for sudden death, and women have lower risk than men for cardiovascular disease including stroke.The causes of these sex differences in sudden death victims, cardiac arrests, and outcomes from cardiovascular or cerebrovascular disease are poorly understood.Our data with CA/CPR suggest that females have better outcomes then males but the implication of estrogen in outcome and estrogens mechanism of action to reduce injury remains uninvestigated.We demonstrated that estradiol administered after CA/CPR is neuroprotective and is mediated via estrogen receptor beta (ER-beta).We also demonstrated that estrogen regulates a gene CART (Cocaine and/amphetamine regulated transcript) which then down regulates an apoptotic gene ERK2 (extra cellular regulated kinase).The down regulation of ERK2, we believe accounts for the protection from neuronal injury following CA/CPR.These data are important because it demonstrated that estrogen is neuroprotective following CA/CPR and it demonstrates the mechanism of action by which estrogen exerts its neuroprotective effect.
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