【摘 要】
：
Patients with medically refractory partial epilepsy who are considered to be candidates for resective epilepsy surgery frequently undergo various tests to assess language dominance and memory includin
【机 构】
：
Cedars Sinai Epilepsy Program and Neurophysiology Lab USA
【出 处】
：
BIT`s 3rd Annual World Congress of NeuroTalk-2012(2012第三届国际神
论文部分内容阅读
Patients with medically refractory partial epilepsy who are considered to be candidates for resective epilepsy surgery frequently undergo various tests to assess language dominance and memory including neuropsychometric testing, Angio-WADA and direct cortical stimulations as to minimize resection of eloquent cortex.Language shifting has been described in patients with childhood onset epilepsy and may have an implication on surgical approach.Neuroimaging studies have shed a light on cortical language organization, with recent findings implicating left and right temporal lobes in speech converging to a left dominant pattern.Attention to presumptive non dominant lobe language mapping is not part of routine language protocols.We use a large array 148 channel biomagnetometer (MEG, 4D Neuroimaging) and multiple tasks (Auditory Word Recognition, Visual Verb Generation and Picture naming) in candidates for resective epilepsy surgery to investigate cortical organization for receptive and productive language function.Laterality indices were calculated.In our cohort 27% demonstrated discordant receptive and productive language with leftward laterality for the Verb generation task, tapping productive speech rightward laterality for the word recognition task tapping receptive language processing.Receptive and Expressive language may have divergent hemispheric dominance in patients with medically refractory partial epilepsy.Right sided receptive language dominance may have implications for surgical planning.MEG with multiple language tasks may have advantages as compared to other tests that sometimes may not assess independently productive and expressive speech.These finding were confirmed by Angio-WADA and direct cortical stimulations.
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