【摘 要】
：
Diagnosis of epilepsy requires recurrent, unprovoked epileptic seizures (ES), but ES can often be provoked by alterations in environment, either external or internal, and either physiological or psych
【机 构】
：
University of Utah USA
【出 处】
：
BIT`s 3rd Annual World Congress of NeuroTalk-2012(2012第三届国际神
论文部分内容阅读
Diagnosis of epilepsy requires recurrent, unprovoked epileptic seizures (ES), but ES can often be provoked by alterations in environment, either external or internal, and either physiological or psychological.Intermittent photic stimulation (IPS) triggers either ES or non-epileptic seizures (NES).Question remains as to how reliable IPS is in differentiating ES and NES.Raw data were collected from 3 patients (PT) undergoing diagnostic Video-EEG monitoring.Protocol consisted of prolonged sessions of repeated administration of IPS trains at varying rate.When inconclusive, protocol was repeated on following days by PT consent.PT experience-based characterization of effective stimulus configurations suggested both modality specific and non-specific variables.PT reported unique psychosensory experiences at clinical onset prior to EEG changes confirming ES.Customary non-motor episodic symptoms did not allow differentiation between aborted ES and NES.Seemingly opposite outcomes of repeated IPS application questions its diagnostic reliability, but suggest that psychophysiological triggers work in 2 steps;first, producing activated brain state below detection threshold, either cognitive or EEG, and second, when effective, initiating cascade of brain processes of epileptic propagation ultimately becoming recognizable as ES.Video-EEG criteria fail to reliably determine point of bifurcation at behavior dissociation, and differentiate epileptic negative affect and panic experiences which can be viewed as displacement or escape behavior with or without awareness.
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