【摘 要】
：
芋螺毒素(Conopeptide,Conotoxin,CTx)是生长于热带海洋中的肉食性软体动物芋螺(genus Conus)分泌的一大类活性多肽,可以用来捕食、防御和威慑竞争者。自然界含有约700多
【机 构】
：
海南大学热带生物资源教育部重点实验室,海口市海洋药物重点实验室,海南海口570228
【出 处】
：
第12届生物毒素研究及医药应用学术大会
论文部分内容阅读
芋螺毒素(Conopeptide,Conotoxin,CTx)是生长于热带海洋中的肉食性软体动物芋螺(genus Conus)分泌的一大类活性多肽,可以用来捕食、防御和威慑竞争者。自然界含有约700多种芋螺,每一种可以分泌超过1000种芋螺毒素肽,且不同种间鲜有重复。由于大多数芋螺毒素可以区分不同种类的离子通道亚型,因此芋螺毒素广泛被用作药理学工具研究离子通道,同时一些芋螺毒素可直接作为潜在的诊断和治疗药物进行开发。
其他文献
大多数蜘蛛毒液中主要成分是富含二硫键的多肽神经毒素和线性α-螺旋的抗菌肽.现在发现狼蛛科蜘蛛多含有抗菌肽分子，而且一些抗菌肽还具有抗肿瘤细胞活性.黑腹狼蛛广泛分
The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of p
The venom of spider is an increasingly valuable library to discover novel componentsfortherapeutic applications and investigating the relationship of the st
Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system.BmK I, a site-3
Since 2006, with the extensive occurrence of thousands injured and dozens of deaths caused by wasp stings, it has become a severe public health concern in C
BmP02, a 28-residue short-chain peptide from the venom of the East-Asian scorpion (Buthus martensi Karsch) has been investigated with a comparatively higher
BmK I (an-like toxin purified from the venom of Eastem Asian scorpion Buthus martensi Karsch) has been identified to a site-3 specific modulator of VGSCs wi
The Chinese brown frog (R.chensinensis David, 1875) was original described at Inkiapo in Shaanxi province of north-central China.In our previous research, 2
目的：海南产αO-芋螺毒素GeXIVA是神经型乙酰胆碱受体(nAChRs) α9α10亚型的特异性强阻断剂.研究发现,α9α 10 nAChR是一些人类疾病的重要靶点,如：治疗神经痛、癌症化疗
烟碱型乙酰胆碱受体(Neuronal nicotinic acetylcholine receptors,nAChRs)是一类广泛分布于中枢及外周神经系统的配体门控离子通道受体.α6β2*nAChRs是其中重要的一种