Martentoxin: a unique ligand of BK channels

来源 :第12届生物毒素研究及医药应用学术大会 | 被引量 : 0次 | 上传用户：QQ81886788

【摘要】

：

　　The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of p

【作者】

：

JieTao[1]JianShi[2]Yong-huaJi;

【机构】

：

Department of Nephrology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine,P.R.Ch

【出处】

：

第12届生物毒素研究及医药应用学术大会

【发表日期】

：

2015年期

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　　The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of physiological functions.Martentoxin (MarTX), a 37-residue peptide purified from the venom of East-Asian scorpion (Buthus martensi Karsch), was capable of blocking large-conductance Ca2+-activated K+ (BK) channels.However, the subtype-selectivity of martentoxin as well as its pharmacological characteristics and mechanisms remained unclear.

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Martentoxin: a unique ligand of BK channels

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