Two Distinct Interaction Model of Synthetic BmP02 on Kv1.3 and Kv4.2

来源 :第12届生物毒素研究及医药应用学术大会 | 被引量 : 0次 | 上传用户：dongwujunye

【摘要】

：

　　BmP02, a 28-residue short-chain peptide from the venom of the East-Asian scorpion (Buthus martensi Karsch) has been investigated with a comparatively higher

【作者】

：

BinWu;Yong-HuaJi;

【机构】

：

Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, P.R.China

【出处】

：

第12届生物毒素研究及医药应用学术大会

【发表日期】

：

2015年期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　BmP02, a 28-residue short-chain peptide from the venom of the East-Asian scorpion (Buthus martensi Karsch) has been investigated with a comparatively higher preference for Kv1.3 over other voltage-gated potassium (Kv) channels [1].However, how BmP02 recognize targets remains unclear.

其他文献

Snake Venom Metalloproteinase Inhibitor from cobra venom

　　Snake venoms contain one of the most potent mixtures of proteases in natural existence and yet the venom gland and proteins in this mixture are refractory t

会议

5-HT2A receptor-Cx43 signaling pathway participating in mirror image pain induced by scorpion sting

　　Serotonin (5-HT), a neuroactive substances, play an important role in the descending inhibitory and descending facilitation system.5-HT receptors, especiall

会议

Identification of a novel Kv1.3 antagonist from the venom of the spider Macrothele raveni

　　The Kv1.3 voltage-gated potassium channel regulates membrane potential and calcium signaling in human effector memory T cells that are key mediators of auto

会议

麻痹性贝类毒素免疫抗原的设计与合成

　　麻痹性贝类毒素(paralytic shellfish poisoning toxins,PSTs)是存在于贝类等海产品体内、摄食后可产生麻痹作用的一类海洋生物毒素的总称,其化学结构为四氢嘌呤衍生物.P

会议

Three tarantula toxins acting on Nav1.5 reveals the diversity of toxin-channel interaction

　　Tarantula toxins potently target voltage-gated sodium channels (Navs) through binding to voltage sensor domains, and they are powerful tools for the investi

会议

黑腹狼蛛抗菌肽的分离和鉴定研究

　　大多数蜘蛛毒液中主要成分是富含二硫键的多肽神经毒素和线性α-螺旋的抗菌肽.现在发现狼蛛科蜘蛛多含有抗菌肽分子，而且一些抗菌肽还具有抗肿瘤细胞活性.黑腹狼蛛广泛分

会议

蜘蛛毒液抗菌肽黑腹狼蛛质谱生物信息学

Martentoxin: a unique ligand of BK channels

　　The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of p

会议

Molecular cloning, expression and solution structure of HWTX-XVIlb1 from the spiderOrnithoctonus huw

　　The venom of spider is an increasingly valuable library to discover novel componentsfortherapeutic applications and investigating the relationship of the st

会议

BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in r

　　Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system.BmK I, a site-3

会议

Deciphering the Venomic Transcriptome of Killer-Wasp Vespa velutina

　　Since 2006, with the extensive occurrence of thousands injured and dozens of deaths caused by wasp stings, it has become a severe public health concern in C

会议

Two Distinct Interaction Model of Synthetic BmP02 on Kv1.3 and Kv4.2

其他学术论文