BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in r

• 作 者: PinYe;Li-MingHua;Yong-HuaJi;
• 机 构: Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, P.R.China
• 出 处: 第12届生物毒素研究及医药应用学术大会
• 发表日期: 2015年期

　　Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system.BmK I, a site-3 sodium channel-specific toxin from scorpion Buthus martensi Karsch, induces pain behaviors in rats.However, the subtypes of VGSCs targeted by BmK I were not entirely clear.