3-DG-老年糖尿病发生的风险因子?

来源 :2013第三届内分泌与代谢大会暨2013第二届糖尿病大会 | 被引量 : 0次 | 上传用户:chanck5800
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  3-脱氧葡萄糖醛酮(3-Deoxyglucosone,3-DG)是一种高活性羰基化合物,除能快速生成晚期糖基化终末产物(Advanced glycation end products,AGEs)外,其本身具有多种生物毒性作用。以往观察研究均较多关注糖尿病患者血清3-DG水平增高,及其与糖尿病慢性并发症的关系。但研究还发现,严格控制血糖后仍有部分高3-DG血症的存在,并可能是糖尿病慢性并发症的独立风险因子之一。现代饮食结构的改变,以及机体衰老对3-DG代谢的影响,推测3-DG水平增高可能在老年糖尿病发病之前就已经存在,而3-DG水平增高是否对血糖调节具有影响作用,是至今相关研究和思考的盲点。
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