【摘 要】
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Our researches have focused on the discovery and development of novel fluorine-18-substituted positron emission tomography(PET) imaging agents.Efficient methods to provide various fluoro-substituted n
【机 构】
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Institute of Pharmaceutical Sciences,National Taiwan University,Taipei 100
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Our researches have focused on the discovery and development of novel fluorine-18-substituted positron emission tomography(PET) imaging agents.Efficient methods to provide various fluoro-substituted nitrobenzenes as synthons are important for design and synthesis of fluorophenyl-substituted PET radiotracers.In this study,a series of fluoro-substituted nitrobenzenes was prepared starting from 2-and 4-fluoro-substituted benzene derivatives.Various nitration reaction conditions were studied and the reactions were monitored by GC.Target fluoro-substituted nitrobenzenes were obtained in 70~90% yields.
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