【摘 要】
：
We have recently published a paper on polyfluorinated bipyridine cisplatins,[PtCl2(4,4-bis(RfCH2OCH2)-2,2-bpy)](Rf=CF3(a),HCF2CF2,C2F5,C3F7,HCF2(CF2)3),and evaluated for their in vitro cytotoxicities
【机 构】
：
Institute of Organic and Polymeric Materials,National Taipei University of Technology,Taipei 106
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
We have recently published a paper on polyfluorinated bipyridine cisplatins,[PtCl2(4,4-bis(RfCH2OCH2)-2,2-bpy)](Rf=CF3(a),HCF2CF2,C2F5,C3F7,HCF2(CF2)3),and evaluated for their in vitro cytotoxicities against a panel of human cancer cell lines,MCF7,MDAMB-231 and A549.This research is an extension of the previous research which involves the synthesis of a series polyfluorinated bipyridine analogues.They are [PtCl2(5,5-bis(RfCH2OCH2)-2,2-bpy)](Rf=CF3(1),HCF2CF2(2),C2F5(3)) and [PtBr2(4,4-bis(RfCH2OCH2)-2,2-bpy)](Rf=CF3(4),HCF2CF2(5),C2F5(6)).These two types of Pt complexs have been successfully synthesized,characterized by multinuclei NMR(1H,19F,and 13C) and FTIR spectroscopy and mass spectroscopy(GC/MS,EI and CI,or FAB).
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