【摘 要】
：
During screening for Hsp90 inhibitor,we find that Nanqiangmycin(NAM)and its analogue acetyl-NAM and nicotinic-NAM has a good potential of as an Hsp90inhibitor which induced the degradation of IKK in t
【机 构】
：
School of Life Sciences,Xiamen University,361005
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
During screening for Hsp90 inhibitor,we find that Nanqiangmycin(NAM)and its analogue acetyl-NAM and nicotinic-NAM has a good potential of as an Hsp90inhibitor which induced the degradation of IKK in tumor cells.It is well known that IKK is an up-stream kinase of NF-κB which is the main pathway to produce the pre-inflammatory factors e.g.TNF-α,IL-1β and IL-6.Our previously study showed that the antitumor agent of Nanqiangmycins have an ability to suppress the activation of TNF-α/NF-κB pathway in HeLa cells.Both western bolt and immune-fluorescent staining results show that RelA(p65),one subunit of NF-κB,enter nucleus can be prohibited by NAMs in HeLa cells,which remind us whether NAM attenuates the release of TNF-α by inhibiting the NF-κB signal pathway or not.
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